Bioinorganic Chemistry

BIOGRAPHY

ACADEMIC POSITION:
Assistant Professor of Medicinal Chemistry, University of Utah

EDUCATION:
• BS University of Utah
• PhD Massachusetts Institute of Technology

RESEARCH INTERESTS:
Despite the therapeutic relevance of many human PTPs, our understanding of their biological substrates, substrate selectivity, cellular regulation and druggability is limited. Research in the Barrios lab focuses on addressing these challenges through the development and application of novel chemical probes, specifically:

1) using fluorogenic probes to investigate PTP activity and regulation during cellular signaling,
2) profiling the substrate selectivities of the PTP family of enzymes, and
3) utilizing PTP substrate selectivity profiles in the design of potent, selective inhibitors and probes.

We are particularly interested in PTPs involved in human autoimmunity and T-cell receptor signaling.