Microbial Physiology & Metabolism

BIOGRAPHY

Major research subjects
Protein translocation across and integration into the membraneand intracellular protein folding and degradation

Major contributions
Discovery of SecY, the central component of translocon

Genetic, biochemical and structural characterization of SecY and SecA and their interactions

Discovery of regulation involving nascent polypeptide-ribosomal tunnel interaction of SecM

Elucidation of the roles and mechanims of FtsH and other membrane-integrated proteases in degradation, assembly and regulation of membrane proteins

Discovery of the protein disulfide bond donor, DsbA, and elucidation of the structure and molecular mechanisms of protein disulfide bond generation by DsbB