Cell Growth & Division

BIOGRAPHY

ACADEMIC POSITION:
Principal Investigator, Institute of Molecular and Cell Biology (IMCB), Singapore

EDUCATION AND PREVIOUS POSITIONS:
Philipp Kaldis received his PhD from the Institute for Cell Biology, Swiss Federal Institute of Technology (ETH), Zürich, Switzerland, in 1994 where he worked on the mitochondrial creatine kinase with Dr Theo Wallimann and Dr Hans Eppenberger. In 1995, he joined Dr Mark Solomon’s laboratory at Yale University, Department of Molecular Biophysics and Biochemistry, New Haven, Connecticut, as a postdoctoral fellow/associate research scientist where he investigated the activation of cyclin-dependent kinases (Cdks). In 2000, Dr Kaldis was appointed as tenure-track investigator at the NCI-Frederick and was promoted to senior investigator with tenure in 2006. In 2007, he joined the Institute of Molecular and Cell Biology (IMCB) in Singapore as principal investigator.

RESEARCH INTERESTS:
Our laboratory investigates the regulation of the cell cycle in vivo by combining mouse genetics with cell biology and biochemistry. We are focusing on the cyclin dependent kinases (Cdks) and all pathways that control or are controlled by Cdks. In addition to the functions of the Cdks under normal conditions, we are actively studying the involvement of Cdks in cancer. Ultimately, we want to define drugable targets in vivo that would lead to improved cancer therapy.