Biomarkers of Rheumatic Disease

BIOGRAPHY

Lars Rogge

Academic positions:
- Director of the Immunoregulation Unit, Department of Immunology, Institut Pasteur, Paris

All industry positions (in last five years):
- None

Research interests:
- Differentiation of naïve CD4+ T lymphocytes into functionally distinct T cell subsets is essential for efficient immune responses against different types of pathogens. On the other hand, polarized effector CD4+ cells are known to play critical roles in the pathogenesis of various immunopathologies, such as autoimmune diseases, allergies and asthma. This indicates T helper cell differentiation must be tightly controlled and that therapeutic modulation of immune responses may have an impact on human diseases.

- Our lab investigates the molecular mechanisms that control the differentiation and function of human T helper cell subsets and analyzes their role in the pathogenesis of inflammatory diseases. We study the signaling pathways, epigenetic modifications and genetic networks involved in T helper cell differentiation and the contribution of distinct T cell subsets in human autoimmune pathologies.

Thoughts on Faculty of 1000 Medicine:
- I think that F1000 Medicine is an efficient tool to keep up-to-date with progress in my field of interest. Furthermore, the condensed form of presentation allows me to rapidly “scan” advances in other areas.