Microbial Physiology & Metabolism

BIOGRAPHY

Dr. Broach is currently serving as Associate Chair and Professor at Princeton University, Department of Molecular Biology. He completed his undergraduate studies at Yale University and was awarded a Bachelor of Science degree in Chemistry in 1969. In 1973, he was awarded a Ph.D. in Biochemistry from the University of California, Berkeley, where he also completed his Predoctoral fellowship in Biochemistry, and Postdoctoral Fellowship in Medical Physics. In addition, he completed a Postdoctoral Fellowship at Cold Spring Harbor Laboratory, upon which he was employed in the capacity of a Staff Scientist. Subsequently, he joined the State University of New York at Stony Brook as an Assistant/Associate Professor, a position he held just prior to serving in his current position at Princeton University.
In the past, Dr. Broach has served as a Postdoctoral Fellow with the American Cancer Society, an Investigator for the American Heart Association, a Fellow with the American Academy of Microbiology, and a Member of the National Institutes of Health�s Genetics Section. He also served as an Associate Editor for the Journal Molecular and Cellular Biology and Associate Editor for the Journal Cell. He also served as Co-Chairman of the 1991 Gordon Conference on Extrachromosomal Elements and Chairman of the 1993 Gordon Conference on Plasmid and Chromosome Dynamics. Dr. Broach was on the Scientific Review Board of the Frederick Cancer Center, Co-Founder/Director of Research for Cadus Pharmaceuticals, Co-Director/Review Board Member for the Life Sciences Research Foundation, He is a retired Editor of Molecular and Cellular Biology, and has published numerous articles in the field (please see page of Publications list for further details).
Dr. Broach's extensive scientific research background includes his studies in the gene expression of Saccharomyces cerevisiae at Princeton University, and the research he has been conducting during the last three years on �Mating Type Silencing and Switching Yeast� for NIH General Medical. The goal of this project is to explore the mechanism by which heterochromatin is established and maintained in yeast, and to examine the structure of the heterochromatin to determine how it precludes access to the transcriptional apparatus. In addition, Dr. Broach is currently involved in a research project on �Ras and Tor Signaling in Yeast� for the National Cancer Institute, in which he is investigating how the cell promotes specific interactions between distant sites on a chromosome in executing a defined developmental program. This project explores the signal transduction pathways that yeast uses to adapt to changing nutrient conditions and focuses on the nature of Ras and Tor signal transduction pathways by identifying the components of the pathways, their interaction, their response to externals signals, and their effects on cell behavior.
As stated above, Dr. Broach was Co-Founder/Director of Research at Cadus Pharmaceuticals Corporation (Cadus), a biotechnology firm with drug discovery programs that focused on G-protein coupled receptors and utilized a core yeast technology for developing drug discovery assays. Areas where G protein-coupled receptors are of therapeutic benefit include cancer, diabetes, central nervous diseases like schizophrenia and Parkinson�s disease and inflammatory diseases like asthma.