Mineral Metabolism & the Kidney

BIOGRAPHY

Orson Moe

Academic Positions:
- Donald W. Seldin Professorship in Clinical Investigation
- The Charles Pak Distinguished Chair in Mineral Metabolism
- Director of The Charles & Jane Pak Center for Mineral Metabolism and Clinical Research-Mineral Metabolism Clinic

Any industry positions (last five years):
None declared

Research interests:
The major focus of the Moe laboratory is to study the mechanisms of regulation of the principal sodium transporter in the kidney, Na /H exchanger type 3 (NHE3). Normal NHE3 function and regulation are essential for the maintenance of normal extracellular fluid volume, blood pressure and acid-base balance. All the following projects are currently involving or will involve trainees:

Regulation of NHE3:-
- Role of protein trafficking
- Role of phosphorylation and binding proteins
- Role of membrane lipids
- Regulation of NHE3 translation
- Regulation of NHE3 degradation
- Regulation of NHE3 in renal ischemia

Any other information: