Cell Signalling

BIOGRAPHY

My laboratory uses insertional mutagenesis and other genetic strategies to identify genes that are involved in oncogenesis, or regulate phenotypic changes in tumor cells. Genes identified via these strategies are used as probes to explore function from the molecular to the animal level. Some of the genes we have identified and exploited to date include Akt1, Tpl2, Gfi-1 and Gfi-1B. Our work highlights the value of genetic studies in animal models for understanding the molecular basis of cancer and other diseases in humans. Today, we use genome-wide insertional mutagenesis screens, in genetically modified animals to identify genes whose oncogenic potential is realized in the context of defined genetic settings. In addition, we use molecular strategies and animal models based on genes identified via our earlier genetic screens, to explore the role of signaling networks in the biology of cancer and in the biology of the immune system.