Russell Chesney - F1000 Section Head (since 16 March 2009)
Department of Pediatrics, Le Bonheur Children's Medical Center, Memphis, TN, USA
BIOGRAPHY
Dr. Russell Chesney has been active in the Children's Foundation Research Center since its inception and has served both on the scientific advisory committee and on the affiliation committee between the University of Tennessee and the Children's Foundation of Memphis.Dr. Chesney has studied amino acid transport by the kidney for more than 30 years. He has been interested in factors that regulate the renal handling of the amino acid taurine. Working with Dr. Xiaobin Han, they cloned the gene for the rat taurine transporter and demonstrated that its expression can be regulated by a variety of mechanisms including dietary exposure as well as a variety of transcriptional factors. Dr. Chesney's work has focused on factors regulating taurine transport and their relationship to cell volume regulation as a means of protecting against renal damage in cell death.
In the future Dr. Chesney will collaborate with Dr. Xiaobin Han to create cell lines and lines of genetically altered mice to test the influence of alterations in the expression of the taurine transporter by the chemotherapeutic agent cisplatin. It is anticipated that these studies will help define the role of taurine in protection against renal damage and to better understand the nature of the renal and cell volume regulation of the taurine transporter gene in both disease and health.
Selected Publications:
Chesney RW. Renal tubular disease. In Pediatric Nephrology for the Primary Care Physician, Barakat A, Chesney RW (eds) American Academy of Pediatrics, Elk Grove Village, 2009
Kaste S, Thomas N, Rai S, Cheon K, McCammon E, Chesney RW, Jones D, Pui CH, Hudson M: Asymptomatic kidney stones in long-term survivors of childhood acute lymphoblastic leukemia. Leukemia 23(1):104-108, 2009
McManus M, Fox H, Limb S, Arango P, Armstrong P, Azizkhan R, Behrman R, Chesney R, Grover A, Gupta VB, Jewett E, Jones MD Jr, Kim WJ, Lewy J, Lighter D, Mulvey H, Pan R, Schwartz R, Sia C, Stille C, Stockman J, Tait V, Tonniges T, Willson P. New workforce, practice, and payment reforms essential for improving access to pediatric subspecialty care within the medical home. Arch Pediatr Adolesc Med 163(3):200-202, 2009
Chesney RW, Hedberg GE, Rogers QR, Dierenfeld ES, Hollis BE, Derocher A, Andersen M. Does taurine deficiency cause metabolic bone disease and rickets in polar bear cubs raised in captivity? Adv Exp Med Biol. 643:325-331, 2009
Han X, Chesney RW. Mechanism of TauT in protecting against cisplatin-induced kidney injury (AKI). Adv Exp Med Biol. 643:105-112, 2009
Han X, Chesney RW. TauT protects against cisplatin-induced acute kidney injury (AKI) established in a TauT transgenic mice model. Adv Exp Med Biol. 643:113-122, 2009
Chesney RW, Hedberg G. Rickets in lion cubs at the London Zoo in 1889: some new insights. Pediatrics, ePub Apr 6, 2009, DOI: 10.1542/peds.2008-3504
Han X, Chesney RW, Yue J. Functional TauT protects against acute kidney injury. J Am Soc Nephrol 20(6):1323-1332, 2009