Biomacromolecule-Ligand Interactions

BIOGRAPHY

ACADEMIC POSITION:
Associate Professor, Department of Biological Chemistry, Weizmann Institute of Science

EDUCATION:
• 1980-1983 BSc with distinction, in food Technology from the Faculty of Agriculture, Hebrew University, Rehovot
• 1985-1987 MSc in Microbiology with distinction. Thesis subject: Characterisation of relA mutations in Escherichia coli
• 1988-1991: Doctoral studies, Institute of Microbiology, Hebrew University, Hadassah Medical School, Jerusalem. Supervisor: Prof Gad Glaser. Thesis subject: Studies of a global control system in prokaryotes mediated by the alarmon – ppGpp
• 1992-1995: Postdoctoral work at the Laboratory of Prof Alan Fersht, MRC unit for protein function and design, Cambridge, UK. Subject: Intra and intermolecular interactions of barstar, the intercellular inhibitor of barnase from Bacillus amyloliquefaciens

MEMBERSHIPS/AWARDS:
• Israel Science Foundation (ISF)
• Minerva
• Human Frontiers

RESEARCH INTERESTS:
We study the basic physico-chemical principles governing protein-protein interactions, and how these relate to complex biological processes. In particular,
our research focuses on the following:

• Kinetics of protein-protein association
• Cooperativity of non-covalent interactions between proteins
• Protein design
• Interferon-receptor interactions, from basic understanding to drug design
• Bioinformatics of protein-protein interactions
• Structural proteomics