Tony Pawson - F1000 Head of Faculty (since 01 November 2001)
Samuel Lunenfield Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
BIOGRAPHY
ACADEMIC POSITION:Principal Investigator and Distinguished Investigator, Samuel Lunenfeld Research Institute, Mount Sinai Hospital
EDUCATION:
- BA Cambridge University (UK)
- PhD London University (UK)
MEMBERSHIPS:
- Fellow of the Royal Society of London (UK)
- Fellow of the Royal Society of Canada
- Foreign member of the National Academy of Sciences (USA)
RESEARCH INTERESTS:
In the Pawson lab, our focus is on studying the mechanisms that underlie intracellular signal transduction. Modular protein domains that mediate protein-protein interactions are critical elements of this process. These modules are typified by the phosphotyrosine binding Src homology 2 (SH2). Since the discovery of SH2 domains, the number of different modules has grown into the dozens, many of which we continue to investigate. Work on the molecular dissection and functional significance of protein-protein interactions, in signal transduction, is a primary focus of the lab. In addition to this, we are also actively working on the molecular signals involved in axon guidance; wiring the cell through protein interactions especially Eph receptors and ephrins.