Pedro Jose - F1000 Section Head (since 28 April 2006)
University of Maryland, USA
BIOGRAPHY
Pedro Jose is Director of Pediatric Nephrology Research and a Professor of the Departments of Pediatrics and Physiology & Biophysics. He is also a member of the Division of Clinical Pharmacology. His specialities are in the areas of pediatrics and nephrology (kidney care) and his interests are in hypertension and cardiovascular research.Education:
Certification (1986) , Pediatrics and Pediatric Nephrology
Fellowship (1979) , Georgetown University Hospital
Certification (1974) , Pediatric Nephrology
Certification (1970) , Pediatrics
Residency (1967) State University of New York, Downstate Medical Center
Internship (1966) State University of New York, Downstate Medical Center
MD (1965) University of Santo Tomas, Philippines,
PhD () Georgetown University,
Research Interests:
The mission of Dr. Jose's laboratory is to study the role of dopamine and adrenergic receptor subtypes and dopamine regulatory genes on sodium transport in specific nephron segments and their role(s) in the pathogenesis of genetic hypertension in humans and in animal models of hypertension.
His work focuses on the integrative physiology of these receptors (wild type, mutants, and single nucleotide polymorphisms) in vivo, as well as in vitro. The molecular and cellular biology of these receptors in (1)specific nephron segments, (2)stably transfected CHO, LTK-, and HEK cells, (3)primary cultures of human renal proximal tubule from hypertensive and normotensive subjects and rat juxtaglomerular apparatus, (4)immortalized renal proximal tubule cells from normotensive and spontaneously hypertensive rats as well as normotensive and hypertensive humans, (5)immortalized mouse renal cells of proximal tubule, cortical collecting duct, medullary collecting duct, and (6)dopamine receptor subtype "knock-out" mice, and (7)transgenic mice overexpressing dopamine regulating genes (e.g., G protein-coupled receptor kinase 4, wild type and variants). Emphasis is placed on studying genes that regulate blood pressure and contribute to the pathogenesis of spontaneous hypertension in animals and in man.
He received a $16 million, five-year grant from the National Institute of Diabetes and Digestive and Kidney Diseases for his research on the renal dopamine-1 receptor defect in hypertension.