Paul Garrity - F1000 Faculty Member (since 08 January 2004)
Department of Biology, Brandeis University, Waltham, MA, USA
BIOGRAPHY
EDUCATION:-California Institute of Technology, PhD, Biology
-Swarthmore College, B.A, Chemistry
RESEARCH SUMMARY:
We are interested in understanding the molecular mechanisms of sensory detection and behavior, focusing on how animals sense and respond to temperature and chemicals using Transient Receptor Potential (TRP) channels and other molecules. In addition to addressing fundamental issues in neuroscience, these studies inform our understanding of the molecular basis of nociception, inflammation and pain in humans. Our work combines Drosophila molecular genetics and behavior with the monitoring of neuronal activity in intact animals, comparative genomics, and ion channel biophysics.
In addition, we are also exploiting thermosensitive TRP channels to create tools for manipulating neuronal activity. Having developed dTRPA1 as a thermogenetic tool for use in Drosophila, our lab is extending this approach to other systems.
EVALUATIONS
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