Cardiovascular Physiology/Circulation

BIOGRAPHY

ACADEMIC POSITION:
Associate Professor, School of Biomedical Sciences and Pharmacy, University of Newcastle

EDUCATION:
• Bachelor of Engineering, University of New South Wales
• PhD, University of New South Wales

MEMBERSHIPS/AWARDS:
• Australian Physiological Society
• Australian Neuroscience Society
• Australian Society for Medical Research
• Australian and New Zealand Vascular Biology Society
• British Pharmacological Society
• 2004 Hunter Medical Research Institute Sparke Helmore/ NBN Award for Research Excellence

RESEARCH INTERESTS:
Investigations are being made on cellular rhythms including those in lymphatics, blood vessels, gastrointestinal tract, heart and specific mood-associated brain nuclei. We have discovered a new mechanism that it is driven by intracellular Ca2+ stores that allow groups of cells to self pace and hence become rhythmic. We are now exploring the relevance of this mechanism in a range of tissues. We are also interested in specific proteins involved in the pacemaker mechanism including inositol 1,4,5-trisphosphate receptors, ryanodine receptors, store operated calcium channels and TRP family proteins. These studies may influence future therapies to control lymphedema, digestive disorders, heart arrhythmias and brain mood states.

We also have a recent patent relating to use of a topical ointment as a first aid treatment against snakebite. This was a surprising outcome that arose from studies investigating whether snake venoms enhance lymphatic pumping and hence accelerate their own delivery. Our preliminary trials indicate topical application of the ointment slows lymphatic transport by some 350% with no obvious adverse effects. The cream will be of particular use for bites to the torso where pressure bandaging is ineffective. It may also be useful as a first aid treatment against bites from other venomous creatures.