Microbiology

BIOGRAPHY

EDUCATION

- MASTER IN SCIENCES (University Paris VII) Biochemistry / Microbiology - 1978
- MD (University Paris VI) - 1979



HOSPITAL GRADES

- 1973: 'INTERNE DES HOPITAUX DE PARIS' 5 years of Residency in Internal Medicine and Infectious Diseases (1974-1979)
- 1981: 'CHEF DE CLINIQUE-ASSISTANT DES HOPITAUX DE PARIS' 4 years as Chief-Resident in Infectious Diseases at the Institut Pasteur Hospital (1981-1985)
- 1985-1990: Head of the Outpatient Unit at the Institut Pasteur Hospital
- 1992-1995: In charge of the development of Clinical Research at Institut Pasteur



RESEARCH POSITIONS

- 1976-1980: Research Fellow at Institut Pasteur in 'Unité de Bactériologie Médicale' (YA Chabbert), under a fellowship of 'Fondation Roux'
- 1980-1981: Post-Doctoral Fellow in the Department of Enteric Diseases, SB Formal, Walter Reed Army Institute of Research, Washington DC, under a fellowship of the French Ministry for Foreign Affairs (1980) and the National Research Council of the USA (1981)
- 1981-1987: Research Assistant at Institut Pasteur in 'Unité des Entérobactéries' (L Le Minor)
- 1987-1989: 'Chef de Laboratoire' at Institut Pasteur in "Unité des Entérobactéries" (L Le Minor)
- 1989: Creation and direction of 'Unité de Pathogénie Microbienne Moléculaire' at Institut Pasteur
- 1994: Professor at Institut Pasteur
- 2000: Professor 'Classe Exceptionnelle' at Institut Pasteur
- 2008: Professor at College de France



SCIENTIFIC ADMINISTRATION

Scientific Administration Institut Pasteur
- 1989-1992: Chairman of the Department of Bacteriology and Mycology of Institut Pasteur
- 1991-1995: Member of the Scientific Council of Institut Pasteur (Secretary, then Vice-Chairman)
- 1995-1999: Medical Director at Institut Pasteur
- 2002: Chairman of the Department of Cell Biology and Infection

Institut National De La Sante Et De La Recherche Medicale (INSERM)
- 1991-1995: Chairman of the Intercommission of Infectious and Parasitic Diseases
- 1995-1998: Member of INSERM Scientific Council

World Health Organization
- 1991-1995: Member of the Steering Committee on Diarrheal Vaccines
- 1992-: Member of the PVD-Task Force on Vaccine Development
- 1993-: Member of the Scientific and Technical Advisory Committee (STAC) of the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases
- 1995-: Chairman of the Steering Committee on Diarrheal Diseases Vaccine development

Ministry of Research and Technology
- 1997-2001: Chairman of the Scientific Council of the National "Programme de Recherche Fondamentale en Microbiologie, Maladies Infectieuses et Parasitaires", Ministère de la Recherche.

Other Institutions
- 2000: Chairman of the Scientific Advisory Board of the Max-Planck-Institute für Infektionsbiologie, Berlin.
- 2000: Vice-Chairman of the Scientific Advisory Board of the Bernhardt Nocht Institute für Tropical Medicine, Hamburg.
- 2002-2003: Vice-Chairman of the Scientific Council of the Fondation pour la Recherche Médicale.
- 2003-: Member of the Scientific Council of the Fondation Bettencourt Schueller Member of the Scientific Advisory Board of the Fondation Louis Jeantet
- 2004-: Chairman of the Scientific Council of the Fondation pour la Recherche Médicale
- 2008-: Professeur au Collège de France



SCIENTIFIC HONOURS

- 1993: EMBO Member
- 1994: Elected Member to the American Academy of Microbiology
- 1994: Chevalier de la Légion d'Honneur
- 1996: Elected Correspondent Member to the French Academy of Sciences
- 2001: Elected Member to the French Academy of Sciences
- 2001: Elected Member to Academia Europea, Cell Biology section
- 2002: Elected Corresponding Member to the French Academy of Medicine
- 2002: Elected Member to the Deutsche Akademie der Natursforscher Leopoldina
- 2003: Officier de l'Ordre National du Mérite
- 2009: Elected Foreign Member of the Royal Swedish Academy of Engineering Sciences



SCIENTIFIC AWARDS

- 1983: "Prix Jacques Monod" for excellence in Molecular Biology
- 1984: "Prix AGIR" from the Pasteur-Weizmann Council
- 1990: "Grand Prix" of the French Academy of Medicine
- 1994: "Prix Louis Jeantet de Médecine" (Geneva, Switzerland)
- 1995: Wellcome Burroughs Visiting Professorship in the Microbiological Sciences for the 1995-96 academic year, The Rockefeller University, NY
- 1996: MacLaughlin Visiting Professorship for the 1995-96 academic year, University of Texas
- 1997: Edwin H. Beachey Visiting Professorship at the University of Tennessee
- 1997: Robert-Koch Prize (Bonn, Germany)
- 1998: Marvin A. Brennecke Visiting Professor at Washington University, St Louis, Missouri
- 1999: Annual “ Frontiers in Vaccinology Lecture ”, Center for Vaccine Development, University of Maryland (25th Anniversary)
- 2000: Carl Friedrich von Siemens Stiftung Lecture, Munich, Germany
- 2000: Invited Visiting Professor of Paediatrics at Harvard Medical School and Visiting Scientist at G.I. Cell Biology Laboratory, Children's Hospital, Boston, Massachussetts
- 2000: Nomination to the rank of Howard Hughes Medical Institute Scholar
- 2000: André Lwoff Medal "for outstanding service to microbiology in Europe" on the occasion of 25th Anniversary (Jubilee) of FEMS
- 2000: 40th ICAAC Lecture and ICAAC annual award "for outstanding contribution in the field of Infectious Diseases".
- 2000: Prix AGF - Athéna - Institut de France
- 2001: Pasteur-Weizmann Scientific Council visiting speaker at the Weizmann Institute, Israel
- 2001: Shipley Lecture and Award, Harvard Medical School, Boston, Massachussetts
- 2001: Invited speaker at the Jubilee symposium organized for the 100th anniversary of the Nobel Prize, Stockholm, Sweden
- 2003: Co-organiser of the Gordon Research Conference 'Molecular Mechanisms of Bacterial Adhesion', Rohde Island.
- 2003: Division B Lecturer, American Society for Microbiology Annual Meeting, Washington DC. < Stanier Public Health Honorary Lecture >, Montreal, Canada
- 2004: Deutsche Gesellschaft für Hygiene und Mikrobiologie Lecturer
- 2005: Nomination to the rank of Howard Hughes Medical Institute Scholar
- 2006: Elected Member of the American Association for the Advancement of Science (AAAS)
- 2006: Invited Lecturer, Nobel Conference, The Karolinska Institute, Stockholm, Sweden
- 2007: External Scientific Member of the Max-Planck-Institute for Infection Biology in Berlin
- 2008 Nomination to the rank of Professeur au Collège de France, Titulaire de la Chaire de Microbiologie et Maladies Infectieuses
- 2008: Awarded ERC Advanced Grant
- 2009: Award of the <GlaxoSmithKline International Member of the Year Award>, American Society for Microbiology (2009)



FUNCTIONS IN SCIENTIFIC JOURNALS

Editor of:
- Infection and Immunity (1992-1998)
- Cellular Microbiology (1998-) (creation of the Journal)

Associate Editor of:
- Research in Microbiology
- Microbes and Infection

Member of the Editorial Boared of:
- Science (Board of Reviewing Editors)
- EMBO Journal (Advisor to Editors for molecular and cellular pathogenesis of infections)
- EMBO Reports (Advisor to Editors for molecular and cellular pathogenesis of infections)
- Microbial Pathogenesis
- FEMS Microbiology Reviews
- Trends in Microbiology
- Infectious Agents and Disease
- International Journal of Medical Microbiology
- PLOS Medicine
- Nature Microbiology



DIRECTION OF THESIS

- Direction of 12 Medical Thesis
- Direction of 20 Scientific (PhD) Thesis



DIRECTION OF POST-DOCS

- Direction of 30 foreign post-docs plus 6 presently in the Laboratory. Fellowships for these post-docs have been awarded by major organisms such as:

- EMBO, Deutsche Forschung Gemeinschaft, Fondation pour la Recherche Médicale, Association pour le Développement de l'Institut Pasteur, Thrasher Research Fund, Pasteur Foundation



PUBLICATIONS

- About 300 publications in peer reviewed international journals
- Recognized among most cited French scientists (ISI, 2000)



PATENTS

- Patents: Four patents on molecular diagnosis of shigellosis and vaccine development.
- Two patents for Nod proteins recognizing peptidoglycan.