Cardiovascular Pharmacology

BIOGRAPHY

ACADEMIC POSITION:
Assistant Professor of Surgery, Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, Boston, MA

RESEARCH INTERESTS:
The main focus of our laboratory is to study the cellular mechanisms of vascular tone under physiological conditions and the changes in these mechanisms in pathological conditions such as coronary artery disease, salt-sensitive hypertension, abdominal aortic aneurysm, varicose veins and other chronic vascular diseases. Projects include investigation of endothelium-dependent mechanisms of vascular relaxation, Ca2+-dependent and Ca2+-independent mechanisms of vascular contraction, role of protein kinases and phosphatases in vascular smooth muscle contraction, mechanisms of gender-specific differences in vascular tone, role of endothelin in salt-sensitive hypertension, and cellular mechanisms responsible for vascular aneurysm formation, varicose veins and other inflammatory vascular disorders.