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Figure 1.
Macroautophagy regulates cross-presentation and intracellular as well as extracellular antigen presentation on major histocompatibility complex (MHC) class II molecules
Autophagosomes, which form isolation membranes around cytoplasmic constituents, fuse with MHC class II loading compartments (MIICs), which are a subset of multivesicular bodies (MVBs). Autophagosomes fuse with MVBs either directly or after fusion with endosomes (forming amphisomes). Autophagic cargo can also escape from the MVBs via exocytosis and can then be efficiently cross-presented by dendritic cells (DCs). |
