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Figure 1.
Glutamate receptor expression on oligodendrocyte lineage cells
Schematic depiction of a myelinating oligodendrocyte (right) that has differentiated from a mitotic progenitor (oligodendrocyte precursor cell [OPC], left), which was in synaptic contact with an unmyelinated axon. OPCs, immature oligodendrocytes, and mature oligodendrocytes express glutamate receptors. Axonal and oligodendrocyte glutamate transporters cause a non-vesicular glutamate release in conditions of energy deprivation such as stroke and secondary ischaemia following spinal cord injury. Whether glutamatergic stimulation of OPCs regulates their differentiation and myelination awaits in vivo evidence. AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, NMDA, N-methyl D-aspartate; mGluR, metabotropic glutamate receptor. |
