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Figure 1.
Model of potential vesicle-uncoating steps
Transport vesicle uncoating may take place in the cytosol prior to tethering (‘1’), at the target membrane following tethering (‘2’), following fusion (‘3’), or a combination of these. See the ‘When and where does uncoating take place?’ section of the text for a detailed explanation. Vesicle coat is represented by heavy dashed lines. A Rab protein is represented by a blue oval. A generic membrane tether (which could be either a multi-subunit tethering complex or extended fibrous tether) is shown as a kinky thick line (magenta with purple core), and SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are shown as helical thin lines. ALG-2, apoptosis-linked gene 2; GAP, GTPase-activating protein. |
