Ron PrywesDepartment of Biological Sciences, Columbia University, New York, New York, USA F1000 Faculty Member (since 10 May 2002)
Department of Biological Sciences
813B Fairchild Center, M.C. 2420
New York, N.Y. 10027
Dr. Prywes works on signal transduction and gene regulation in two systems. First, he has worked on growth factor induction of cellular immediate early gene transcription. This has focused on regulation of the c-fos and c-jun proto-oncogenes. These genes are regulated by the transcription factors, SRF, MEF2 and ATF1, among others. Growth factor activated signalling pathways that activate these genes include the MAPKs ERK1/2 and ERK5 and the Rho and Rac GTPases.
Second, Dr. Prywes has worked on the ER stress/unfolded protein response. This response is stimulated by unfolded proteins in the endoplasmic reticulum and activates the transcription factor ATF6. ATF6 is an ER transmembrane protein that ER stress causes to move to the Golgi where a part is cleaved from the membrane so that it can translocate to the nucleus and activate target genes.
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