Victor HsuDepartment of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, MA, USA F1000 Faculty Member (since 10 December 2010)
Associate Professor, Department of Medicine, Harvard Medical School
Associate Immunologist, Rheumatology, Immunology and Allergy, Brigham And Women's Hospital
We are interested in understanding mechanisms of vesicular transport and are also applying these insights to elucidating physiology and disease mechanisms. Coat proteins initiate, and thereby define, intracellular transport pathways. We have been studying the Coat Protein I (COPI) complex as a model system to understanding basic mechanisms of vesicle formation. We have also identified a new clathrin complex for endocytic recycling, a pathway critical for many cellular events. In recent years, we have discovered that COPI cooperates with critical lipids to bend the membrane bilayer in achieving vesicle formation. Our insights have also led us to elucidate molecular mechanisms that underlie cell migration, metabolic homeostasis, and viral pathogenesis.
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