Sam Y HongNational Cancer Institute, Frederick, MD, USA F1000 Associate Faculty Member (since 12 April 2010)
Sam Y Hong is an Associate Faculty Member who works with Faculty Member Larry K Keefer to recommend the scientific literature in their field.ACADEMIC POSITION:
Cancer Research Training Awardee, National Cancer Institute
O2-vinylated diazeniumdiolates have been shown to be selectively metabolized by CYP450. Preliminary in vitro and in vivo data show that targeting NO to organs rich in these enzymes, such as the liver, may have therapeutic benefits. Using an amino acid-based prodrug approach, we are developing selective NO donors with good toxicological profiles. We are currently investigating the structure/activity relationships as well as the transport and metabolism of these prodrugs.
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