Marie-France CarlierLab d'Enzymologie et Biochimie Struc, Centre National de la Recherche Scientifique (CNRS), Gif-sur-Yvette, France F1000 Faculty Member (since 03 July 2001)
Academic: ESPCI (chemistry); PhD in Physics, 1976 Paris
ERC advanced grant 'Forcefulactin' 2010-2015
Our aim is to understand the molecular and physical mechanisms producing force and movement, by directed polymerization of cytoskeletal polymers actin filaments and microtubules in response to cell signalling. These motile processes are essential for cell migration and tumor invasion, embryo development, immune response, synapse plasticity, tissue repair, and the spread of intracellular pathogens. Our strategy is to analyze, biochemically, the control of these polymers dissipative self-assembly by regulatory proteins, in combination with a biomimetic/biophysical 'bottom-up' approach: we reconstitute self-organizing, autonomous motile systems, mimicking cell reality. To address these issues at the interface between biology, physics, and chemistry, we are an interdisciplinary group, composed of molecular biologists, biochemists, structuralists, and biophysicists. Current projects involve the mechanism of nucleation of actin filaments by protein machineries (formins, filament branching with Arp2/3 complex); the multifunctionality of WH2 domains in Spire, Cordon-Bleu, VopF, N-WASP, etc.; the use of microfluidics in TIRF analysis of single filament dynamics.
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