Barry RouseDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA F1000 Faculty Member (since 26 July 2001)
Lindsay Young Distinguished Professor of Microbiology, Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee
University of Bristol, 1965 Bachelor of Veterinary Science with honors
University of Guelph, 1967 MSc
University of Guelph, 1970 PhD
Walter and Eliza Hall Institute of Medical Research, 1970-72
University of Bristol, 1997 DSc
Section Editor, Journal of Immunology
Member, Editorial Board of Virology, Viral Immunology, Journal of Virology
Principal Organizer, Keystone Symposium on Molecular Aspects of Viral Immunity, 2001
Alcon Award for Vision Research, 2000
Immunobiology and immunopathology of virus infections.
Current Projects: Our research uses various animal models of Herpes simplex virus (HSV) infections in an attempt to understand the immunopathogenesis of HSV infection and its control by vaccines. In one model, herpetic stromalkeratitis (HSK) lesions are immunopathological. We are attempting to understand the molecular and cellular mechanisms involved in the pathogenesis of HSK with a view to defining means of controlling these lesions which are an important cause of human blindness. The disease process appears to result from a pathological immune reaction against viral proteins or host proteins induced following infection or by a bystander mechanism of activation. The mechanism of immunopathology as well as its modulation is under investigation. Other projects deal with defining optimal means of inducing protective immunity against HSV. Current research emphasizes DNA vaccines given via mucosal routes. A range of in vivo and in vitro test systems are used to evaluate efficacy. In addition, we are attempting to define the relevance of cross-priming during immunization against viruses and determining how the cross priming process is mediated in vitro and in vivo.
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