Professor David D Chaplin, MD, PhD, is chairman of the University of Alabama Department of Microbiology.
Before coming to UAB in the spring of 2001, Dr Chaplin served as professor of medicine, genetics, and molecular microbiology in the department of internal medicine at the Washington University School of Medicine in St Louis.
Dr Chaplin joined Washington University in 1984 as an assistant professor of medicine and molecular microbiology. In 1995, he was named professor of medicine, genetics and molecular microbiology. Chaplin received a medical degree and a PhD in cell and developmental biology from Washington University in 1980. He did his residency in internal medicine at Parkland Memorial Hospital in Dallas and then pursued postdoctoral training in genetics at Harvard University.
He is a fellow of the American Association for the Advancement of Science and has been elected to the American Society for Clinical Investigation and the Association of American Physicians. He also belongs to the American Academy of Allergy, Asthma and Immunology, and the American Association of Immunologists.
Dr Chaplin’s laboratory aims to define the ways innate immune stimuli modulate allergic inflammatory responses that are manifest in tissues through the action of the adaptive immune response. He has a special interest in the ways commensal and pathogenic microbes that are present in the lung alter allergic inflammatory responses such as those that underlie asthmatic inflammation. He is testing the hypothesis that airway microbes impact the quality and quantity of asthmatic inflammation largely through their induction of myeloid-derived regulatory cells (MDRC). Lung and airway MDRC, defined by Dr. Chaplin’s laboratory in 2011, constitute several discrete populations of cells that determine the overall inflammatory tone in the tissues through their production of cytokines, chemokines, and reactive nitrogen and oxygen free radical species. Dr Chaplin’s laboratory demonstrated in studies using a mouse model that superoxide-producing MDRC dramatically accentuate airway hyperresponsiveness after exposure to aerosolized antigen. In contrast, populations of nitric oxide-producing MDRC blunt airway hyperresponsiveness, suggesting that the nitric oxide/superoxide axis may be a valuable target for future development of novel anti-asthmatic therapeutics.
In the role of Faculty Member, David Chaplin contributes recommendations and reviews to the Leukocyte Activation Section in the Immunology Faculty, writing brief accessible comments to summarize the value of the articles and adding rating score.
The Faculty comprises Heads of Faculty, Heads of Section, Faculty Members and Associate Faculty Members, as well as an International Advisory Board.
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