Brian HemmingsProtein Kinase Lab, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland F1000 Faculty Member (since 10 March 2009)
1990- Senior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel
1975 PhD, University of East Anglia, Norwich, UK
1972 BSc, University of Nottingham, Nottingham, UK
1983-1989 Junior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel
1982-1983 FMI Research Associate, The Rockefeller University, New York
1980-1982 MRC Research Fellow, Medical Sciences Institute, University of Dundee, Dundee
1977-1980 Fogarty Visiting Fellow, NIH, Bethesda, Md., USA
1975-1977 Research Fellow, Biochemisches Institut der Universität, Freiburg im Breisgau, Germany
2009 Elected Fellow of the Royal Society of London
2009 Executive Committee Basel Signaling Alliance
2009 Gairdner Foundation Medical Award Subcommittee
2004 and 2005 In ISI '100 Most Cited Scientists in Biology and Biochemistry'
2004 Novartis Corporate Research Award for Scientific Excellence
2004 Swiss Bridge Award
2001-2012 Member, Scientific Committee, Swiss Cancer League
2000 Cloëtta Prize, Prof Dr Max Cloëtta Foundation, Zurich
2000 Japanese Biochemical Society 'JB' award
2000 Visiting Professor at the Faculty of Medicine, Katholieke Universiteit, Leuven
1999 Philip Godfrey Memorial Lecture of the Biochemical Society Meeting, Glasgow
1998-1999 Member, Evaluation Committee, Göran Gustafsson Foundation (The Royal Swedish Academy of Sciences)
1996 Member, EMBO
1972 Belper Graduation Prize, University of Nottingham, Nottingham
Judging simply by the abundance of protein kinase and protein phosphatase genes, protein phosphorylation is a very important regulatory mechanism. Our current work focuses on the role of these enzymes in eukaryotic signaling pathways and their possible implications in human diseases.
Signal transduction pathways in mammalian cells function through the coordinated activation, or inactivation of protein kinases and phosphatases localized in the cell membrane, cytoplasm or nucleus. Many human diseases result from deregulation of signal transduction pathways; for example, the proliferation signal pathways of cancer cells are permanently upregulated following mutation of key regulatory enzymes.
Our current research activities focus on targeting novel kinases involved in the development and progression of glioblastoma, ovarian cancer and lymphoma with the ultimate aim of finding new personalized therapeutic strategies.
Brian Hemmings has been added to your "Faculty I'm Following" page in MyF1000
Follow/Unfollow any Faculty via their recommendations, biography pages, or MyF1000