Professor: Department of Pathology, University of Washington
1973 PhD, University of Washington
1967 MD, Boston University
American Heart Association, Council on Arteriosclerosis
American Society for Cell Biology
American Society for Investigative Pathology
North American Vascular Biology Organization
The major effort of Dr Schwartz's laboratory is on growth control of vessel wall cells and smooth muscle lineages. The work is largely based on concepts of cell cycle regulation derived from research in developmental biology and tumor biology applied here to atherosclerosis and hypertension. The laboratory has shown that smooth muscle cells belong to distinct lineages or subsets. Unique properties of these subsets may account for monoclonality of atherosclerotic lesions and for the special properties of the arterial intima that contribute to progression of atherosclerosis. Most of the lab's effort is directed at specific functions of subsets as dictated by their characteristic patterns of gene expression. These functions include subset-specific promoter function, contraction of gels by adhesive proteins, and control of programmed cell death.
Current projects include:
1) Clonal variation in lineage-specific genes by smooth muscle cells from blood vessels;
2) Role of cell adhesion molecules in plaque contraction;
3) Identification of lineage-specific genes by rapid sequencing;
4) Role of apoptosis in vascular remodeling.
Current cloning efforts in the lab are directed at identifying new genes that are specific for human smooth muscle subsets.
In the role of Faculty Member, Stephen Schwartz contributes recommendations and reviews to the Integrative Physiology Section in the Physiology Faculty, writing brief accessible comments to summarize the value of the articles and adding rating score.
The Faculty comprises Heads of Faculty, Heads of Section, Faculty Members and Associate Faculty Members, as well as an International Advisory Board.
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