Senior Investigator, Laboratory of Immune Cell Biology
Our lab's current focus is on the transcriptional control of T cell development and function, notably the gene expression programs that control the 'choice' by T cell precursors of the CD4 or CD8 lineage in the thymus, and that perpetuate lineage differentiation in mature T cells.
Recent areas of interest include the following:
1. The function of two zinc finger transcription factors, Gata3 and Thpok (also known as Zbtb7b or cKrox) during CD4 cell differentiation in the thymus. We proposed that Gata3 and Thpok act as specification and commitment factors, respectively, during CD4-lineage differentiation in the thymus. We are currently evaluating how these factors promote the expression of other genes characteristic of the CD4 lineage.
2. The function of Thpok in mature CD4 T cells. We found that Thpok maintains the 'CD4 identity' as its deletion in mature (post-thymic) CD4 T cells that had developed as Thpok-sufficient results in the re-expression of CD8 and of cytotoxic genes. We are currently investigating the mechanistic bases of these functions, and notably its relationship with Thpoks repression of Runx3, a Runx-family transcriptional regulator required for proper CD8 cell differentiation and cytotoxic gene expression.
3. The function of Ets1, the founding member of a large family of transcription factors that bind specific DNA sequences typically centered over a GGAA tetranucleotide motif, in CD8 differentiation. We showed that Ets1 is required for the proper termination of CD4 expression during the differentiation of MHC I-restricted thymocytes, at least in part because it promotes Runx3 expression.
In the role of Faculty Member, Remy Bosselut contributes recommendations and reviews to the Leukocyte Development Section in the Immunology Faculty, writing brief accessible comments to summarize the value of the articles and adding rating score.
The Faculty comprises Heads of Faculty, Heads of Section, Faculty Members and Associate Faculty Members, as well as an International Advisory Board.
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