Roland KanaarDepartment of Cell Biology & Genetics, Erasmus Medical Center, Rotterdam, Netherlands F1000 Faculty Member (since 15 December 2010)
Scientific Staff, Molecular Radiation Biology Group
'Pionier' research grant from the Netherlands Organization for Scientific Research in 2000.
He serves on the editorial boards of a number of scientific journals including EMBO J and Molecular Cell.
Roland Kanaar studied during his graduate research the action of an enhancer in site-specific DNA recombination and elucidated how nucleoprotein complexes assembled at distant sites along a DNA chain communicate with each other to provide selectivity during recombination. His post-doctoral work aimed at understanding how proteins and RNA interact to achieve accurate but flexible recognition of splice sites.
His current research addresses the mechanisms and biological relevance of genome surveillance processes with particular emphasis on homologous DNA recombination and DNA double-strand break repair. Genome surveillance is essential to prevent chromosomal abnormalities, which in their turn may lead to hereditary diseases, cancer or cell decay. Contrary to the existing dogma, his group showed that DNA double-strands breaks in mammalian cells can be repaired through homologous recombination. The work was granted a prestigious 'Pionier' research grant from the Netherlands Organization for Scientific Research in 2000.
Currently, we are pursuing an integrated approach using biochemical, protein structural, cell biological and mouse genetics methods to unravel different aspect of genome maintenance processes from the molecular to the whole animal level.
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