Wendy Hanna-RoseDepartment of Biochemistry & Molecular Biology, Pennsylvania State University, University Park, PA, USA F1000 Faculty Member (since 23 February 2011)
Associate Professor of Biochemistry and Molecular Biology
Associate Department Head for Undergraduate Studies
BA Anderson University
PhD Harvard University
Postdoc University of Colorado at Boulder
Society for Developmental Biology (SDB)
Genetics Society of America (GSA)
American Society of Cell Biology (ASCB)
The overarching goal of the Hanna-Rose lab is to understand how development is genetically programmed. We use the development of the reproductive structures in the nematode Caenorhabditis elegans as a research model. Our research is focused in two areas.
NAD metabolism: NAD+ is a central molecule in metabolism and a co-substrate for NAD+ consuming enzymes that regulate key biological processes, such as longevity and stress responses. While the biochemistry of NAD+ biosynthesis from vitamin B3 is well studied, the biological impacts of disruption of this biosynthetic pathway in a multicellular organism are not. We have made the novel discovery that elimination of the first enzyme in the NAM to NAD+ salvage biosynthesis pathway (PNC-1) causes developmental and functional defects in the reproductive system. We aim to understand how perturbation of metabolism and / or NAD+ consumer activity during development contributes to reproductive function.
Tubulogenesis: The cell rearrangements contributing to tubulogenesis in different organs and even within different areas of a single biological tube are varied. We aim to understand molecular mechanisms directing the development of biological tubes. By studying C. elegans vulval tubulogenesis, we recently revealed a novel mechanism for de novo lumen formation involving migration of one cell through an epithelial cell layer, and we developed a model that requires phospholipase function for maintenance of this luminal space. Current research is aimed at testing this model.
Wendy Hanna-Rose has been added to your "Faculty I'm Following" page in MyF1000
Follow/Unfollow any Faculty via their recommendations, biography pages, or MyF1000