• Scientific Director, Group Leader of the Laboratory of Genetic Instability, Ageing and Cancer
• Professor, of Medicine
• Associate Member of Medical Genetics, Experimental Medicine and Pathology and Laboratory Medicine
• Genetic instability, aging and cancer
• Replication and repair of telomeric DNA
• Stem cell biology and lymphocyte function
• Fluorescence in situ hybridization, flow cytometry and cell sorting
The major focus of the research in Dr Lansdorp's laboratory is on the role of genetic instability in aging and cancer. Ongoing studies are very diverse in nature, ranging from molecular studies on the role of helicases in the genomic stability of guanine-rich DNA (using C.elegans as a model) to studies of chromosome ends (telomeres) in the biology of normal and malignant cells. An area of specific interest is the role of telomeres and telomerase in stem cells and lymphocytes.
Current studies focus on the molecular mechanisms of telomere attrition in relation to DNA replication and repair in normal and malignant cells. Such studies include manipulation of known and novel pathways involved in telomere biology and function using lentiviral mediated gene transfer into lymphocytes and various stem cells.
In the role of Faculty Member, Peter Lansdorp contributes recommendations and reviews to the Non-hematopoietic Stem Cells Section in the Hematology Faculty, writing brief accessible comments to summarize the value of the articles and adding rating score.
The Faculty comprises Heads of Faculty, Heads of Section, Faculty Members and Associate Faculty Members, as well as an International Advisory Board.
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