Rudolf JaenischDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA F1000 Head of Faculty (since 18 July 2001)
Our long-range goals are to understand epigenetic regulation of gene expression in mammalian development and disease. An important question is to understand the different epigenetic conformations that distinguish differentiated cell states and to define strategies to transdifferentiate one differentiated cell type into another. Embryonic stem cells are of major significance because they have the potential to generate any cell type in the body and, therefore, are of great interest for regenerative medicine. A major focus of our work is to understand the molecular mechanisms that allow the reprogramming of somatic cells to an embryonic pluripotent state and to use the potential of patient specific pluripotent cells to study complex human diseases.
Embryonic stem cells and the control of self-renewal, Nuclear Cloning and the Reprogramming of the Genome, In vitro reprogramming of somatic cells to a pluripotent state, Cancer.
Rudolf Jaenisch, pioneer in the field of transgenics and researcher at the Whitehead Institute, MIT, is one of the Heads of Faculty for Genomics & Genetics at F1000Prime. Here, Professor Jaenisch talks to us about his research into stem cells and the reprogramming of somatic cells to a pluripotent state – and what the application of this technology could mean for the study of complex diseases like Parkinson’s and Alzheimer’s. [Video uploaded 16 May 2013]
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