Alan McNeillyMRC Centre for Reproductive Health, Queen's Medical Research Institute, Edinburgh, Scotland, UK F1000 Faculty Member (since 07 January 2010)
Our major aim is to determine how ovarian follicular development is controlled both from within the ovary and by the pituitary, so that at ovulation only good eggs are released leading to the birth of healthy babies.
As model systems we use cell and tissue culture, transgenic mice to study the effects of gene addition or deletion, and sheep as model mono-ovular species having very similar reproductive endocrinology and ovarian biology to women. We collaborate with clinical colleagues to examine human tissues.
We are particularly interested in the mechanisms of differential gonadotrophin secretion by the pituitary, and the influence of the TGFß superfamily of growth factors in regulating pituitary function and ovarian follicle growth and maturation. Our research benefits from many collaborations with groups throughout the world.
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