Meenakshisundaram Ananthanarayanan

BIOGRAPHY

ACADEMIC POSITION:
Senior Research Scientist in Medicine (Digestive Diseases)

PREVIOUS POSITIONS:
• Associate Professor of Pediatrics, Mount Sinai School of Medicine, New York, NY
• Research Scientist, Department of Pediatrics, Yale University School of Medicine, New Haven, CT
• Associate Research Scientist, Yale University School of Medicine, New Haven, CT
• Research Associate, University of Southern California School of Medicine, Los Angeles, CA
• Postdoctoral Fellow, Scripps Clinic and Research Foundation, La Jolla, CA

EDUCATION:
Postgraduate Institute of Medical Education and Research 1975-— 1980, Chandigarh, India

RESEARCH INTERESTS:
Our laboratory's main interest is focussed on understanding the molecular mechanisms of bile formation with respect to the role of bile acid transporters and how they are dysregulated in various intra- and extrahepatic cholestatic liver disease. Current work is centered on the molecular details of dissecting the various coregulators that assemble at the promoters of genes for Na-cotransporting polypeptide(Ntcp), Bile salt export pump (Bsep) and Multidrug resistance protein 2(Mrp2). Animal models utilized consist of various strains of mice in which LPS (Lipopolysaccharide) is injected to induce intrahepatic cholestasis and bile duct ligation is performed surgically to simulate extrahepatic cholestasis.

HOME PAGE
http://medicine.yale.edu/intmed/people/ananth_meena.profile