Yamini DalalLaboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA F1000 Faculty Member (since 08 October 2010)
Head, Chromatin Structure and Epigenetic Mechanisms, Laboratory of Receptor Biology and Gene Expression
EDUCATION AND BACKGROUND:
Yamini Dalal received her PhD in 2003 for work performed in Arnold Stein's laboratory at Purdue University, where she studied nucleosome positioning in vitro and in vivo. She found that nucleosome positions in vitro could be predicted by reiterations of alternating stiff and flexible DNA motifs within the mouse genome. These sequence motifs correlated with nucleosome spacing at a subset of loci in mouse tissues. She also studied how linker histone H1 could influence nucleosome spacing, and changes in chromatin structure in aging mice.
Yamini next worked with Dr Steven Henikoff at the Fred Hutchinson Cancer Research Center from 2003-2007 to study histone variants which encode intrinsic variability in the chromatin fiber and result in a diversity of biological functions. This work resulted in the observation that centromeric histone variants form an unusual chromatin fiber.
In 2008, Yamini moved to NCI to start her own group, which focuses on histone variants and the mechanism by which they encode epigenetic information in the human cancer genome.
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