Mark SearceySchool of Pharmacy, University of East Anglia, Norwich, Norfolk, UK F1000 Faculty Member (since 26 January 2007)
Chair of Medicinal Chemistry and Head of the School of Pharmacy at the University of East Anglia
BSc(Hons) Chemistry, Loughborough University
PhD Hatfield Polytechnic
Post-doctoral research with Gerry Gallacher and Keith Brocklehurst at the Faculty of Basic Medical Sciences, Queen Mary College, University of London on polyclonal catalytic antibodies
Fellow of the Royal Society of Chemistry and Chartered Chemist
Member of the American Chemical Society
Committee Member of the RSC Nucleic Acids Group
Committee Member of the Society for Medicines Research.
Member of the EORTC-PAMM Drug Discovery Committee.
Research is focussed on interesting targets for the development of new therapeutics with a particular interest in targeting DNA and protein-proteins interactions. The group uses both solution and solid phase synthesis to make compounds based upon natural products or purely from synthetic sources. Natural products under investigation include the duocarmycins, quinaldopeptin and the neopetrosiamides. Therapeutic targets include quadruplex DNA, Holliday junctions, the Nrf2 pathway in inflammation and PSD-95.
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