Pharmacokinetics & Drug Delivery Recommendations
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The College of Pharmacy, University of Michigan, Ann Arbor, MI, USA
School of Pharmacy, University of California, San Francisco, San Francisco, CA, USA
Center for Cancer Research, Laboratory of Metabolism, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK
- » Drug delivery (incl. gene therapy and stem cells as delivery systems; blood-brain barrier; liposomes, polymers and drug delivery)
- » Drug-drug, drug-disease, drug-nondrug remedy Interactions
- » Metabolism (phase I and phase II enzymes)
- » Pharmacokinetics, pharmacodynamics and bioavailability
- » Therapeutic drug monitoring
- » Transporters plus biliary and renal elimination
The author reviews the principles of designing compounds with optimized physicochemical properties for penetration into the brain. He begins by describing the impact of our current understanding of brain physiology on the brain penetration of...
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