Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5.
Sci Signal. 2011; 4(168):ra22
Nakajima Y, Akaogi K, Suzuki T, Osakabe A, ..., Murayama A, Kimura K, Inoue S, Yanagisawa J. Nakajima Y, Akaogi K, Suzuki T, Osakabe A, Yamaguchi C, Sunahara N, Ishida J, Kako K, Ogawa S, Fujimura T, Homma Y, Fukamizu A, Murayama A, Kimura K, Inoue S, Yanagisawa J. Sci Signal. 2011; 4(168):ra22
This paper provides a new insight into the regulation of androgen-independent cancers by hormones. Despite their hormone refractoriness, many human prostate cancers express considerable amounts of androgen receptors (AR) and estrogen receptors (ER). This study, for the first time, reports that estradiol and the antiestrogen ICI...
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