Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.
Sci Signal. 2011; 4(163):ra13
Richard Firtel1 and Pascale Charest2
14 Apr 2011
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New Finding
This study reveals the monoubiquitination of K-Ras as a novel regulatory mechanism controlling K-Ras' activity and signaling specificity.
The reversible post-translational modification of proteins, such as phosphorylation, acetylation and ubiquitination, is an efficient way of modulating protein function and increasing signaling...
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