LRP6 mediates cAMP generation by G protein-coupled receptors through regulating the membrane targeting of Gα(s).
Sci Signal. 2011; 4(164):ra15
Murat Bastepe1 and Serap Turan2
14 Apr 2011
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New Finding
This is a very interesting study because the authors showed that low-density lipoprotein receptor-related protein 6 (LRP6) has a critical role in the intracellular localization of the heterotrimeric stimulatory G protein and is thus required for receptor-activated cAMP generation.
cAMP is a second messenger utilized by many heterotrimeric...
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