CREBBP mutations in relapsed acute lymphoblastic leukaemia.
Nature. 2011 Mar 10; 471(7337):235-9
Mullighan CG, Zhang J, Kasper LH, Lerach S, ..., Pui CH, Baker SD, Brindle PK, Downing JR. Mullighan CG, Zhang J, Kasper LH, Lerach S, Payne-Turner D, Phillips LA, Heatley SL, Holmfeldt L, Collins-Underwood JR, Ma J, Buetow KH, Pui CH, Baker SD, Brindle PK, Downing JR. Nature. 2011 Mar 10; 471(7337):235-9
This study is interesting because it provides evidence for a high frequency of CREB binding protein (CBP, also known as CREBBP) mutations in patients with relapse of acute lymphoblastic leukemia (ALL).
ALL is the most common malignancy in children and youths. However, the mechanism of treatment failure in ALL is not well defined....
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