CREBBP mutations in relapsed acute lymphoblastic leukaemia.
Nature. 2011 Mar 10; 471(7337):235-9
Fredric Wondisford1 and Ling He2
09 Nov 2011
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New Finding
This study is interesting because it provides evidence for a high frequency of CREB binding protein (CBP, also known as CREBBP) mutations in patients with relapse of acute lymphoblastic leukemia (ALL).
ALL is the most common malignancy in children and youths. However, the mechanism of treatment failure in ALL is not well defined....
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