Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity.
Nat Med. 2011 Apr; 17(4):479-87
Flach TL, Ng G, Hari A, Desrosiers MD, ..., Tschopp J, Muruve DA, Amrein MW, Shi Y. Flach TL, Ng G, Hari A, Desrosiers MD, Zhang P, Ward SM, Seamone ME, Vilaysane A, Mucsi AD, Fong Y, Prenner E, Ling CC, Tschopp J, Muruve DA, Amrein MW, Shi Y. Nat Med. 2011 Apr; 17(4):479-87
In the field of vaccinology, adjuvants have taken prominence as a hot field of research. This publication potentially answers a vexatious question -- the mechanism of action of alum, the grand-daddy of human adjuvants, which until now has remained unknown.
The adjuvant alum (potassium aluminum sulfate) has been used in human vaccines...
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