Inactivating mutations of acetyltransferase genes in B-cell lymphoma.
Nature. 2011 Mar 10; 471(7337):189-95
Pasqualucci L, Dominguez-Sola D, Chiarenza A, Fabbri G, ..., Gaidano G, Rabadan R, Brindle PK, Dalla-Favera R. Pasqualucci L, Dominguez-Sola D, Chiarenza A, Fabbri G, Grunn A, Trifonov V, Kasper LH, Lerach S, Tang H, Ma J, Rossi D, Chadburn A, Murty VV, Mullighan CG, Gaidano G, Rabadan R, Brindle PK, Dalla-Favera R. Nature. 2011 Mar 10; 471(7337):189-95
This article describes novel recurrent mutations in two acetyltransferase genes, CREBBP and EP300, in follicular lymphoma (FL) and diffuse large B cell lymphoma (DLBCL), and thereby implicates histone modification and impaired acetylation of non-histone proteins as an important pathogenetic event in the biology of these common nHodgkin...
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