Inactivating mutations of acetyltransferase genes in B-cell lymphoma.
Nature. 2011 Mar 10; 471(7337):189-95
Randy Gascoyne
17 Mar 2011
This article describes novel recurrent mutations in two acetyltransferase genes, CREBBP and EP300, in follicular lymphoma (FL) and diffuse large B cell lymphoma (DLBCL), and thereby implicates histone modification and impaired acetylation of non-histone proteins as an important pathogenetic event in the biology of these common nHodgkin...
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