Bitter taste receptors and alpha-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying.
Proc Natl Acad Sci U S A. 2011 Feb 1; 108:2094-9
Janssen S, Laermans J, Verhulst PJ, Thijs T, Tack J, Depoortere I. Proc Natl Acad Sci U S A. 2011 Feb 1; 108:2094-9
Earlier work suggested that intake of a potential toxin that activates the bitter taste receptor T2R pathway in the gut decreases the rate at which food passes through the stomach and lowers the drive for continued eating, presumably a response designed to inhibit further ingestion of toxin. However, this study suggests that the lower...
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