Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast.
Cell Mol Life Sci. 2011 Apr; 68(8):1395-403
Kobayashi T Cell Mol Life Sci. 2011 Apr; 68(8):1395-403
This interesting review examines the long-standing puzzle of the large number of rDNA repeats and puts forward the hypothesis that large numbers of rDNA copies are important for genome integrity and stability, may be the evolutionary origin of heterochromatin, and may be involved in genome instability leading to evolutionary adaptations.
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