CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens.
Immunity. 2011 Jan 28; 34(1):85-95
Asano K, Nabeyama A, Miyake Y, Qiu CH, ..., Tomura M, Kanagawa O, Fujii S, Tanaka M. Asano K, Nabeyama A, Miyake Y, Qiu CH, Kurita A, Tomura M, Kanagawa O, Fujii S, Tanaka M. Immunity. 2011 Jan 28; 34(1):85-95
This study brings new insights into relevant antigen presenting cell (APC) populations that cross-present apoptotic cell-associated antigens injected subcutaneously. Additionally, mechanisms of antigen uptake are addressed. Lastly, it is interesting that physical barriers (not mechanistic ones) and cell localization within the lymph...
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