A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis.
Sci Signal. 2010; 3(151):ra87
Boucher J, Macotela Y, Bezy O, Mori MA, Kriauciunas K, Kahn CR. Sci Signal. 2010; 3(151):ra87
This study reveals the unexpected, novel finding that insulin and insulin-like growth factor receptors ([IRs] and [IGF-1Rs], respectively) function as double swords in the control of cell survival.
While it has been known for years that they transmit the anti-apoptotic action of insulin and IGF-1, they are now shown to also act as...
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