Cholinergic interneurons control local circuit activity and cocaine conditioning.
Science. 2010 Dec 17; 330(6011):1677-81
Anthony Grace and Kathryn Gill
09 Mar 2011
This study utilizes the powerful optogenetic approach exploring the role of cholinergic interneurons in the nucleus accumbens (NAc) in cocaine conditioning. The optogenetic technique allows for exquisite temporal control over neural activation and inhibition of select neural populations, in this case choline acetyltransferase (ChAT)-expressing interneurons in the NAc. Consequently, with this technique the participation of the relatively sparse interneuron population in the NAc in cocaine conditioning can be tested along with measuring electrophysiologically the impact on the main output neurons, medium spiny neurons (MSNs)...
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