Regulation of Ras localization by acylation enables a mode of intracellular signal propagation.
Sci Signal. 2010; 3(140):ra68
Gregory Cosgrove and Jason Wells
29 Dec 2010
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Novel Drug Target
The manuscript by Lorentzen et al. is novel as it defines the role of acylation in the subcellular localization and propagation of the Ras signaling pathway.
It has been previously demonstrated that Ras function differs based on its activation state and subcellular localization {1}. Ras activation is controlled via guanine nucleotide...
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