Claudin-5 controls intercellular barriers of human dermal microvascular but not human umbilical vein endothelial cells.
Arterioscler Thromb Vasc Biol. 2013 Mar; 33(3):489-500
Kluger MS, Clark PR, Tellides G, Gerke V, Pober JS. Arterioscler Thromb Vasc Biol. 2013 Mar; 33(3):489-500
This elegant study by Kluger et al. compares junctional integrity, junctional ultrastructure and the contribution of claudin-5 and VE-cadherin to the barrier function of cultured human umbilical vein endothelial cells (HUVEC) and human dermal microvascular endothelial cells (HDMEC). HDMEC were found to form tighter cell layers (higher transendothelial electrical resistance, less permeability)...
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