A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop.
Nucleic Acids Res. 2012 Nov 1; 40(20):10334-44
Wanrooij PH, Uhler JP, Shi Y, Westerlund F, Falkenberg M, Gustafsson CM. Nucleic Acids Res. 2012 Nov 1; 40(20):10334-44
At just over 16,500 base pairs, the mitochondrial genome of human cells is tiny. It remains vital by encoding tRNAs and oxidative phosphorylation enzymes whose genes have (mysteriously) not yet been shed to the nucleus. Regulation of the copy number of mitochondrial DNA within each mitochondrion is potentially important in disease...
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